TY - JOUR T1 - A rare case of autoimmune limbic encephalitis: an uncharted territory! JF - Neurosciences Journal JO - Neurosciences (Riyadh) SP - 292 LP - 297 DO - 10.17712/nsj.2017.4.20170150 VL - 22 IS - 4 AU - Hatim Ibrahim AU - Abdulelah N. Al Jasser AU - Sonia A. Khan AU - Kalthoum G. Tlili Y1 - 2017/10/01 UR - http://nsj.org.sa/content/22/4/292.abstract N2 - Autoimmune encephalitis is rare. Several auto- antibodies are described in autoimmune encephalitis. We describe a case of autoimmune limbic encephalitis associated with positive voltage gated potassium channel (VGKC) antibodies and positive leucine-rich glioma inactivated protein 1 antibodies (LGI1). A 33-year-old Saudi housewife, she presented with 2 months history of cognitive deterioration and recurrent left facio-brachial dystonic seizures followed by generalized tonic clonic seizures. At times the seizures are preceded by rising epigastric aura and shortness of breath. The neurological examination was normal apart from upgoing left plantar reflex. She had borderline IQ of 76 with impaired verbal fluency and impaired visual and verbal memory. Magnetic resonance imaging of the brain showed right mesial temporal non-enhancing lesion. Cerebrospinal fluid examination was positive for LGI1 and VGKC. Optimal seizure control was achieved with immunotherapy. ER -