RT Journal Article SR Electronic T1 Resting-State fMRI findings in patients with first-Episode idiopathic epilepsy before and after treatment JF Neurosciences Journal JO Neurosciences (Riyadh) FD Prince Sultan Military Medical City SP 316 OP 319 DO 10.17712/nsj.2017.4.20160650 VO 22 IS 4 A1 Peng-Fei Qiao A1 Guang-Ming Niu YR 2017 UL http://nsj.org.sa/content/22/4/316.abstract AB Objectives: To detect resting-state functional MRI (rsfMRI) changes and their relationships with the clinical curative effect of anti-epileptic drugs (AEDs) for complex partial seizures (CPS) in epilepsy patients using the fractional amplitude of low frequency fluctuation (fALFF).Methods: rfMRI data from 14 CPS patients enrolled between June 2015 and June 2016 in Department of Neurology, Affiliated Hospital of Inner Mongolia Medical University were retrospectively investigated and compared with findings from 14 healthy age-, gender-, handedness-, and education-matched subjects. The patients were treated with first-line antiepileptic drugs for 12 weeks before undergoing a second rfMRI scan. fALFF data were processed using REST and SPM8 software. Whole-brain data were compared between the 2 groups.Results: The abnormal findings in CPS patients significantly decreased or disappeared after AED treatment.Conclusion: Measuring fALFF is useful for identifying brain functional changes in patients with first-episode epilepsy before and after treatment. Performing rfMRI is useful for evaluating treatment responses and may provide new insight into the pathophysiological mechanisms of epilepsy.