- Cases of Marchiafava-Bignami disease (MBD) post-bariatric surgeries.
| Yıldırım Z et al8 | Bachar M et al9 | Salazar G et al10 | Alshimemeri S et al (our paper) | |
|---|---|---|---|---|
| Demographics | 58yo, F | 44yo, F | 62yo, F | 45yo, F |
| Type of bariatric surgery | Intragastric balloon | Roux-en-Y gastric bypass | Not specified | Laparoscopic sleeve gastrectomy |
| Other comorbidities | None | Schizophrenia and bipolar disorder. | None | None |
| Interval between surgery and presentation | 7 days | 23 years | 5 years | 40 days |
| Laboratory findings | Hypokalemia | High MCV, low albumin, elevated LFTs, high ammonia levels. | Low vitamin B12 and B9 levels | Hypernatremia, elevated LFTs and high glucose and protein in her CSF |
| Lesions’ location | Splenium of the CC | Splenium of the CC and posterior limb of internal capsule | The entire corpus callosum. | Splenium of the CC and cerebellar peduncles |
| Treatment | IV fluids, IV K+, metoclopramide, Vitamin supplementation, antipsychotics. | Vitamin replacement, MgSO4, antipsychotics, corticosteroids. | Vitamin replacement, Anti-Epileptics. | IV fluids, Vitamin replacement, Diphenhydramine, and metoclopramide |
| Recovery | Complete | Complete | Substantial recovery, however incomplete | Substantial recovery, however incomplete |
| Follow-up period | 14 days | 10 days | 3 months | 6 months |
F: Female, MCV: Mean cell volume, LFTs: Liver function tests, CSF: Cerebrospinal fluid, CC: Corpus callosum.