Table 1

- Implications of recommendation’s strength.

Strength of RecommendationDefinitionImplications for stakeholders
Strong RecommendationThe benefits of the intervention clearly outweigh the risks, and the quality of evidence is high.Clinicians should follow this recommendation in most situations. Patients can be confident in the benefits of the intervention.
Conditional RecommendationThe benefits of the intervention outweigh the risks, but the quality of evidence is lower or there is uncertainty.Clinicians should consider this recommendation, but individual patient circumstances and preferences should guide decision-making. Patients should be informed about the uncertainty and involved in the decision process.
No RecommendationEvidence is lacking to recommend the intervention.Clinicians should use their judgment and consider patient preferences. Further research is required to clarify the overall effectiveness.
Weak Recommendation AgainstThe risks of the intervention outweigh the benefits, but the evidence is low in quality.Clinicians should generally avoid this intervention, but individual cases may warrant its use. Patients should be knowledgeable of the potential risks.
Strong Recommendation AgainstThe risks of the intervention clearly outweigh the benefits, and the quality of evidence is high.Clinicians should not use this intervention. Patients should be made aware of the strong evidence against its use.