- Strength and certainty of evidence for the recommendations on the preventive therapy and complementary and alternative medicine.
| Recommendation | Strength of recommendation | Certainty of evidence | Percentage of panel agreement |
|---|---|---|---|
| 14. For the prevention of episodic or chronic migraine, we recommend using propranolol over no treatment. | Strong | Moderate | 100% |
| 15. For the prevention of episodic or chronic migraine, we recommend using topiramate over no treatment. | Strong | Moderate | 100% |
| 16. For the prevention of episodic or chronic migraine, we suggest using propranolol over topiramate. | Conditional | Low | 100% |
| 17. For the prevention of episodic or chronic migraine, we suggest using valproate over no treatment. | Conditional | Very low | 100% |
| 18. For the prevention of episodic or chronic migraine, we suggest using erenumab over no treatment. | Conditional | Moderate | 82% |
| 19. For the prevention of episodic or chronic migraine, we suggest using fremanezumab over no treatment. | Conditional | Moderate | 91% |
| 20. For the prevention of episodic or chronic migraine, we suggest using galcanezumab over no treatment. | Conditional | Moderate | 82% |
| 21. For the prevention of episodic or chronic migraine, we suggest using eptinezumab over no treatment. | Conditional | Moderate | 82% |
| 22. For the prevention of chronic migraine, we suggest using botulinum toxin over no treatment. | Conditional | Very low | 100% |
| 23. For the prevention of chronic migraine, we suggest using greater occipital nerve block over no treatment | Conditional | Very low | 91% |
| 24. For the prevention of episodic or chronic migraine, we suggest using atogepant over no treatment. | Conditional | Low | 100% |
| 25. For the prevention of episodic or chronic migraine, we recommend using amitriptyline over no treatment (strong recommendation, low certainty of evidence). | Strong | Low | 100% |
| 26. For patient with low serum vitamin D level and chronic migraine, we suggest using vitamin D replacement over no treatment. | Conditional | Low | 82% |