Table 3

Clinical data of patients experiencing fetal/neonatal malformation or stillbirth.

Sr #Seizure SemiologyMedication usedFrequency of seizures during pregnancyMalformation CategoryMalformation Name
Patient 1Generalized seizureCBZ 900 mg/dayIncreasedIntrauterine deathSevere intrauterine growth restriction leading to intrauterine fetal death
Patient 2Focal seizureCBZ 1000 mg/dayLMT 200 mg/dayDecreasedFacial malformationCleft lip and cleft palate
Patient 3Generalized seizureVPA 500 mg/dayLMT 50 mg/dayUnchangedIntrauterine deathFetal anencephaly leading to still birth
Patient 4Focal seizureCBZ 400 mg/dayUnchangedOrgan malformationTetralogy of Fallot
Patient 5Generalized seizureVPA 1250 mg/dayLMT 800 mg/dayUnchangedOrgan malformationAtrial septal defect
Patient 6Generalized seizureNo drug useUnchangedFacial + Organ malformationFetal gastroschisis along with cleft palate
CBZ - carbamazepine, VPA - valproic acid, LMT - lamotrigine