- Demographic and clinical differences between the myasthenia gravis subgroups.
| Characteristics | Ocular n=84 | Bulbar n=40 | Generalized n=23 | P-value |
|---|---|---|---|---|
| n (%) | ||||
| Age Mean ±SD | 35.6±16.1 | 36.1±19.2 | 25.6±10.2 | 0.03* 0.043** |
| Gender | ||||
| Male | 25 (29.8) | 11 (27.5) | 4 (17.4) | 0.497 |
| Female | 59 (70.2) | 29 (72.5) | 19 (82.6) | |
| Anti AChR antibody | ||||
| Positive | 80 (95.2) | 30 (75) | 20 (87) | 0.004 |
| Anti-MuSK antibody | ||||
| Positive | 0 (0) | 8 (20) | 0 (0) | 0.000 |
| Double seronegative | 4 (4.8) | 4 (10) | 3 (13) | |
| NCS | ||||
| Decremental response | 33 (39.3) | 20 (50) | 12 (52.2) | 0.002 |
| Normal | 11 (13.1) | 4 (10) | 9 (39.1) | |
| Not done | 40 (47.6) | 16 (40) | 2 (8.7) | |
| Treatment | ||||
| Pyridostigmine | 7 (8.3) | 2 (5) | 5 (21.7) | 0.000 |
| Azathioprine | 0 (0) | 4 (10) | 0 (0) | |
| Pyridostigmine, prednisolone, with or without azathioprine | 65 (77.4) | 18 (45) | 11 (47.8) | |
| Pyridostigmine, prednisolone, with or without azathioprine, and one dose IVIg | 2 (2.4) | 8 (20) | 0 (0) | |
| Pyridostigmine, prednisolone, and mycophenolate | 2 (2.4) | 6 (15) | 3 (13) | |
| Pyridostigmine, prednisolone, with or without azathioprine, and monthly IVIg | 8 (9.5) | 2 (5) | 4 (17.4) | |
| Thymectomy | ||||
| Done | 55 (65.5) | 18 (45) | 19 (82.6) | 0.009 |
| Not done | 29 (34.5) | 22 (55) | 4 (17.4) | |
| Treatment response | ||||
| Controlled | 59 (70.2) | 23 (57.5) | 19 (82.6) | 0.106 |
| Not controlled | 25 (29.8) | 17 (42.5) | 4 (17.4) | |
| CT chest | ||||
| Prominent thymus | 19 (22.6) | 11 (27.5) | 0 (0) | 0.003 |
| Thymoma | 9 (10.7) | 8 (20) | 0 (0) | |
| Normal | 56 (66.7) | 21 (52.5) | 23 (100) | |
| Histopathology | ||||
| Thymic hyperplasia | 35 (41.7) | 13 (32.5) | 9 (39.1) | 0.000 |
| Thymoma | 9 (10.7) | 4 (10) | 0 (0) | |
| Normal | 11 (13.1) | 1 (2.5) | 10 (43.5) | |
| Clinical state at the end of follow up | ||||
| Ocular | 7 (8.3) | 0 (0) | 0 (0) | 0.003 |
| Bulbar | 0 (0) | 4 (10) | 0 (0) | |
| Generalized | 77 (91.7) | 36 (90) | 23 (100) | |
| Serology | ||||
| Positive | 82 (97.6) | 38 (95) | 20 (87) | 0.104 |
| Negative | 2 (2.4) | 2 (5) | 3 (13) | |