- Characteristics of phaeohyphomycosis cases at our tertiary hospital in Riyadh, Saudi Arabia.26,31,32*
Case No. | Organ Involved Other Than the Brain | Underlying Medical Condition | Surgery | Antifungal Used | Outcome at 90 d | Duration of antifungal therapy for patients who survived (in months) |
---|---|---|---|---|---|---|
1 | Disseminated | None | No | AmB, ITZ, Vori, Caspo | Died | |
2* | Disseminated | ALL | Yes | AmB, ITR | Survived | 33 |
3 | Only cerebral | Kidney Transplant | Yes | AmB | Died | |
4 * | Cerebral | Kidney Transplant | Yes | AmB, ITZ, Posa | Survived | 36 |
5 | Cerebral | None | Yes | AmB | Died | |
6 | Meninges | AML | No | AmB, ITZ | Died | |
7 | Disseminated | CGD | Yes | ITZ, terbinafine, flucytosine | Survived | Still on treatment |
8 | Cerebral | Kidney transplant | Yes | Vori, Caspo | Died | |
9 | Cerebral | Liver Cirrhosis | Yes | L-AmB, Posa | Died | |
10 | Cerebral | Liver transplant | Yes | L-AmB, Posa | Died | |
11 | Cerebral and sinuses | None/pregnant | Yes | Caspo, L-Amb, Posa, Vori | Survived | Still on treatment |
12* | Cerebral | Renal transplant | Yes | L-AmB, Vori | Died | |
F - female, M - male, DM - diabetes mellitus, AmB - Amphotericin B, Vori - Voriconazole, Caspo - Caspofungin, ITZ - Itraconazole, L-AmB -Liposomal Amphotericin B, 5-FC - 5-flourocytocine, KTZ - Ketoconazole, ALL - acute lymphoblastic leukemia, AML - acute myeloid leukemia, MF - myelofibrosis, * |
*Copyright permission from Al-Abdely HM, Alkhunaizi AM, Al-Tawfiq JA, Hassounah M, Rinaldi MG, Sutton DA. Successful therapy of cerebral Phaeohyphomycosis due to Ramichloridium mackenziei with the new triazole posaconazole. Med Mycol 2005; 43: 91-95.
Al-Mohsen IZ, Sutton DA, Sigler L, Almodovar E, Mahgoub N, Frayha H, et al. Acrophialophora fusispora brain abscess in a child with acute lymphoblastic leukemia: review of cases and taxonomy. J Clin Microbiol 2000; 38: 4569-4576.
Alamri M, Alghamdi H, Althawadi S, Mutabaggani M, Dababo MA, Alajlan F, et al. Invasive fungal infection of the brain caused by Neoscytalidium dimidiatum in a post-renal transplant patient: A case report. Med Mycol Case Rep 2021; 34: 27-31.