Table 2

- Pediatric sleep disorders pharmacotherapy.

Disease / DrugPotential side effects
Chronic insomnia
MelatoninHeadache, dizziness, bed-wetting
Antihistamines (diphenhydramine)Dizziness, increase in the thickness of lung secretions
Narcolepsy
MethylphenidateLoss of appetite, suppression of growth, exacerbation of anxiety, nervousness,
Dextroamphetamine, amphetamine- dextroamphetamine mixtureLoss of appetite, suppression of growth, exacerbation of anxiety, nervousness
Modafinil, armodafinilHeadache, precipitation of Stevens-Johnson syndrome, decreases the potency of concurrently administered oral contraceptives
Sodium oxybateTremor, constipation, bed-wetting, exacerbation of sleep apnea, weight loss, exacerbation of depression
Cataplexy
Sodium oxybateTremor, constipation, bed-wetting, exacerbation of sleep apnea, weight loss, exacerbation of depression
Venlafaxine, protriptyline, clomipramineDrowsiness, weight gain, tremor
Fluoxetine, sertralineNervousness, insomnia, increased risk of suicidal thoughts
Restless leg syndrome
Elemental irononstipation and abdominal discomfort
GabapentinDrowsiness, nausea
ClonazepamDrowsiness, tolerance
Obstructive sleep apnea
Mild to moderate OSA: intranasal corticosteroids plusNasal irritation
leukotriene inhibitor (montelukast).Nausea, headache, dizziness
Non-REM sleep parasomnias
ClonazepamDrowsiness, tolerance
L-5-hydroxytryptophanNausea
Circadian sleep-wake disorders
MelatoninHeadache, dizziness, bed-wetting