Table 1

- Clinical data of the 21 NF1 patients in 10 families.

Pedigree number	Family history	Patient number	Individual	Age at diagnosis (year)	Age at onset (year)	Gender	>5 CALMs
1	Yes	1	III:4	20	3	Female	Yes
2	No	2	II:2	16	Infancy	Female	Yes
3	Yes	3	III:2	12	8	Female	Yes
		4	II:1	42	6	Male	Yes
		5	III:1	14	6	Male	Yes
		6	I:1	66	10	Male	Yes
4	Yes	7	II:1	56	Infancy	Male	Yes
		8	III:2	28	Infancy	Female	Yes
5	Yes	9	II:2	55	18	Male	Yes
		10	III:1	16	10	Male	Yes
6	Yes	11	III:1	25	Infancy	Female	Yes
		12	II:4	49	Infancy	Male	Yes
7	Yes	13	III:1	52	2	Female	Yes
		14	II:1	76	2	Male	Yes
		15	II:2	72	2	Female	Yes
		16	IV:2	30	2	Male	Yes
8	Yes	17	I:2	40	Infancy	Female	Yes
		18	II:1	9	Infancy	Female	Yes
9	Yes	19	II:1	33	16	Male	Yes
		20	I:1	62	10	Male	Yes
10	No	21	II:1	43	Infancy	Female	Yes

CALMs, café-au-lait macules; NA, not available; -, none.