Table 1

Differential diagnoses of drug resistant epilepsy.

DiagnosisExamples
None epileptic eventsShuddering attacks, self-gratification, panic attacks, tics, pseudo seizures, dystonic dyspepsia
Improper managementIncorrect diagnosis or classification, poor compliance, under treatment
Intractable epilepsy syndromeLGS, infantile spasms, dravet syndrome, Doose syndrome
Lesional epilepsyCortical dysplasia, mesial temporal sclerosis, cortical tumors, hamartomas
Treatable inherited metabolic epilepsiesPlease refer to Table 2
Neuro-metabolic disorderAmino acid or organic acid disorders, urea cycle disorders.
Neurodegenerative disorderProgressive myoclonic epilepsy, neuronal ceroid lipofuscinosis, mitochondrial cytopathy