Comparison of the treatment characteristics between AD-m and AD-c groups.
| Treatment characteristics | AD-m | AD-c | t/Z/χ2 | P-value |
|---|---|---|---|---|
| n (%) | ||||
| Patients (n) | 47/238 (19.74) | 76/238 (31.93) | ||
| Manic switch | ||||
| Present | 30 (63.82) | 28 (36.84) | 7.440a | 0.006 |
| Absent | 17 (36.18) | 48 (63.16) | ||
| +AD-type | ||||
| SSRI | 29 (61.7) | 48 (63.16) | 19.260a | <0.001* |
| TCA | 15 (31.9) | 5 (6.58) | ||
| Venlafaxine | 0 (0) | 6 (7.89) | ||
| Mirtazapine | 3 (6.4) | 17 (22.37) | ||
| Combined agent | ||||
| Lithium | - | 56 (73.7) | - | - |
| AC | 16 (21.1) | |||
| AP | 4 (5.2) | |||
| Mean dose (SD), (mg) | ||||
| ++++SSRI | 20.98 (5.3) | 22.87 (9.87) | 1.208b | 0.229 |
| +++TCA | 118.76 (78,65) | 116.55 (96.76) | 1.221c | 0.889 |
| Venlafaxine | - | 93.7 (37.5) | - | |
| +++Mirtazapine | 42.76 (12.65) | 38.17 (14.76) | 1.522c | 0.064 |
| ++++MED | 22.68 (10.87) | 22.12 (10.43) | 0.284b | 0.776 |
| ++++Age (SD) | 40.29 (11.98) | 42.56 (12.39) | 0.999b | 0.319 |
| +++Age at onset of disease (SD) | 25.13 (7.93) | 24.85 (7.9) | 0.998c | 0.841 |
| +++Duration of disease (SD) | 14.99 (8.15) | 19.87 (10.76) | 2.512c | 0.006* |
| Mean duration (months) | 5.43 (6.79) | 12.65 (15.43) | 3.090c | 0.002* |
Chi Square, Chi Square with Yates Correction,
↵+ Fisher Exact Chi Square,++Chi Square,
↵+++ Mann Whitney U test,
↵++++ Student t Test, a Chi Square,
↵b t value,
↵c Z value. AD - antidepressant, SSRI - selective serotonin reuptake inhibitors, TCA - tricyclic antidepressants, AC - anticonvulsant, AP - antipsychotic, MED - mean equivalent dose, NS - not Significant (p>0.05).
↵* p<0.05 statistically significant