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Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index

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Abstract

Background

Based on in vitro studies, it has been hypothesized that 1,25-dihydroxy vitamin D (1,25-vit D) may promote weight gain in humans, but previous studies have demonstrated conflicting results regarding the association between serum 1,25-vit D and body mass index (BMI).

Aim of the study

To evaluate the relation between serum 1,25-vit D and BMI.

Methods

Two thousand one hundred and eighty-seven subjects, recruited from a metabolic and medical lifestyle management clinic, were included in a cross-sectional study. BMI, 25-hydroxy vitamin D (25-OH-vit D) and 1,25-vit D were measured. The cohort was divided according to BMI in five groups (<25, 25–29.9, 30–34.9, 35–39.9 and >39.9 kg/m2). Statistical analyses were performed with multiple linear regression models. Age and gender were used as explanatory covariates.

Results

With increasing BMI group, there was a significant decrease in both serum 25-OH-vit D and 1,25-vit D (P < 0.001). Those with BMI > 39.9 kg/m2 had 24% lower serum 25-OH-vit D levels and 18 % lower 1,25-vit D levels than those with BMI < 25 kg/m2.

Conclusions

There is an inverse association between BMI and the serum levels of 25-OH-vit D and 1,25-vit D. This makes it highly unlikely that high levels of circulating 1,25-vit D contribute to the development of obesity.

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Authors and Affiliations

  1. Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway

    Steinar Konradsen, Harald Ag & Rolf Jorde

  2. Dr. Fedon Lindberg’s Clinic, Oslo, Norway

    Fedon Lindberg & Sofie Hexeberg

  3. Dept. of Internal Medicine B, University Hospital of North Norway, 9038, Tromsø, Norway

    Rolf Jorde

Authors
  1. Steinar Konradsen
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  2. Harald Ag
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  3. Fedon Lindberg
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  4. Sofie Hexeberg
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  5. Rolf Jorde
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Corresponding author

Correspondence to Rolf Jorde.

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Konradsen, S., Ag, H., Lindberg, F. et al. Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr 47, 87–91 (2008). https://doi.org/10.1007/s00394-008-0700-4

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  • DOI: https://doi.org/10.1007/s00394-008-0700-4

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