Abstract
Recent work shows that two molecules with major roles in synaptic plasticity--CaMKII and the NMDA receptor--bind to each other. This binding activates CaMKII and triggers its autophosphorylation. In this state, it may act as a memory switch and strengthen synapses through enzymatic and structural processes.
MeSH terms
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Amino Acid Sequence
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
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Humans
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Long-Term Potentiation / physiology
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Memory / physiology*
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Molecular Sequence Data
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Neuronal Plasticity / physiology*
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Phosphorylation
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Receptors, AMPA / metabolism
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Receptors, N-Methyl-D-Aspartate / metabolism*
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Synapses / physiology*
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Synaptic Transmission / physiology
Substances
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NR2B NMDA receptor
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Receptors, AMPA
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Receptors, N-Methyl-D-Aspartate
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Calcium-Calmodulin-Dependent Protein Kinases