Abstract
Plasma concentrations of soluble tumor necrosis factor alpha (TNF-alpha) receptor type I (sTNF-RI) were assessed in two complex regional pain syndrome (CRPS) patient groups (n = 30 and n = 16) and healthy controls (n = 25). Patients with CRPS and mechanical hyperalgesia had higher levels of sTNF-RI (1,661.8 +/- 146.8 pg/mL) compared with those with CRPS with identical clinical appearance but without hyperalgesia (1,155.9 +/- 56.3 pg/mL) and controls (1,239.5 +/- 42.9 pg/mL). This study suggests involvement of TNF-alpha in mechanical hyperalgesia of CRPS.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Age of Onset
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Aged
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Aged, 80 and over
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Complex Regional Pain Syndromes / blood*
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Complex Regional Pain Syndromes / physiopathology
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Edema / blood
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Edema / etiology
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Edema / physiopathology
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Female
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Ganglia, Spinal / metabolism
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Ganglia, Spinal / physiopathology
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Humans
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Hyperalgesia / blood*
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Hyperalgesia / physiopathology
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Male
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Middle Aged
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Nerve Fibers, Myelinated / metabolism
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Nerve Fibers, Unmyelinated / metabolism
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Neuralgia / blood
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Neuralgia / physiopathology
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Neurogenic Inflammation / blood
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Neurogenic Inflammation / physiopathology
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Nociceptors / metabolism
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Nociceptors / physiopathology
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Pain Measurement
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Pain Threshold / physiology
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Receptors, Tumor Necrosis Factor, Type I / blood*
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Sex Factors
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Skin Temperature / physiology
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Tumor Necrosis Factor-alpha / metabolism*
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Up-Regulation / physiology
Substances
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Receptors, Tumor Necrosis Factor, Type I
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Tumor Necrosis Factor-alpha