A 57-year-old woman presented with an escalation of her headaches which ultimately progressed to multiple strokes and death. MRI/MRA demonstrated diffuse vasospasm and other causes of stroke were excluded on premortem investigation and postmortem examination. Reversible MRI abnormalities, vasospasm on angiogram and fatal migrainous infarction have been previously reported; however, no previous case with this combination of clinical, imaging, and postmortem findings has been documented.