Abstract
Ramichloridium mackenziei is a dematiaceous fungus that usually causes cerebral phaeohyphomycosis. We describe the aspiration cytology findings of a case of cerebral abscess caused by R. mackenziei in a 66-yr-old Saudi woman who had a long standing history of diabetes mellitus and a recent diagnosis of systemic lupus erythematosus. She was on long-term corticosteroid therapy. The patient developed rapidly progressive multiple brain abscesses and died despite aspiration of the abscess and administration of intravenous amphotericin B lipid complex and voriconazole.
(c) 2007 Wiley-Liss, Inc.
MeSH terms
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Aged
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Amphotericin B / therapeutic use
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Antifungal Agents / therapeutic use
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Ascomycota / isolation & purification*
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Biopsy, Needle
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Brain Abscess / microbiology
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Brain Abscess / pathology*
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Brain Abscess / therapy
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Central Nervous System Fungal Infections / microbiology
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Central Nervous System Fungal Infections / pathology*
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Central Nervous System Fungal Infections / therapy
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Combined Modality Therapy
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Diabetes Complications
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Diabetes Mellitus
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Fatal Outcome
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Female
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Humans
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Lupus Erythematosus, Systemic / complications
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Pyrimidines / therapeutic use
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Triazoles / therapeutic use
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Voriconazole
Substances
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Antifungal Agents
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Pyrimidines
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Triazoles
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Amphotericin B
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Voriconazole