Recent biomedical discoveries have revolutionized the concept and understanding of
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic, …

Objective Cardiovascular risks are globally elevated in South Asians, but this masks important
ethnic subgroup differences in risk factors, such as hypertension, which have not been …

Abnormally activated RAS proteins are the main oncogenic driver that governs the
functioning of major signaling pathways involved in the initiation and development of human …

Phytoalexins play a significant role in the defense response of plants. These secondary
metabolites, which are synthesized de novo in response to diverse forms of stress, including …

Diabetic retinopathy (DR) is a primary cause of blindness in which damage occurs to the
retina due to an accretion of sugar levels in the blood. Therefore, prior detection, classification, …

Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of
human diseases including cancer. In this line, now it has become evident that ROS level/…

Tyrosine kinases belong to a family of enzymes that mediate the movement of the phosphate
group to tyrosine residues of target protein, thus transmitting signals from the cell surface to …

Early-stage detection of leukemia is a critical determinant for successful treatment of the
disease and can increase the survival rate of leukemia patients. The factors limiting the current …

The constitutive activation of Janus Kinase/Signal Transducer and Activator of Transcription
(JAK/STAT) signal transduction is well elucidated in STAT3-mediated oncogenesis related …

The global burden of breast cancer (BC) is increasing significantly. This trend is caused by
several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug …