Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with genetic
and clinical heterogeneity. The interplay of de novo and inherited rare variants has been …

Objectives Patients with epilepsy have a high risk of accidents and injuries, resulting in
minimized physical activity and social withdrawal. Therefore, we surveyed the prevalence and …

Background Mutations in AFG3L2, a gene encoding a subunit of the mitochondrion m-AAA
protease, cause spinocerebellar ataxia type 28 and recessive spastic ataxia type 5. …

Objectives: To assess the quality of life for epilepsy patients in Saudi Arabia. Epilepsy, one
of the most prevalent chronic neurological conditions in the world, frequently results in a low …

Objectives: To measure the burden of insomnia and daytime sleepiness (DTS) and their
effects on sleep quality, and the risk factors of poor quality of sleep. Methods: We conducted a …

Epilepsy, one of the most prevalent chronic neurological diseases, can cause severe morbidity
as well as mortality. A mutation of the KCNMA1 gene results in a rare genetic disease …

The in vitro cytotoxicity of some substituted quinazolinones, 1–15, was evaluated using NCI (10
µM) in a full NCI 59–cell line panel assay. Relative to the reference drug, imatinib (PCE = …

Cyclin-dependent kinases (CDKs) are promising targets in chemotherapy. In this study, we
report a series of 2-anilinopyrimidine derivatives with CDK inhibitory activity. Twenty-one …

… The 4-methylpyridinyl- moiety was imbedded in a hydrophobic sub-pocket created by
amino acids Ala 35, Pro 58, and Try 64. Examining the binding pocket by the surface …

… for measuring the BZ was that facial width is taken between the most lateral points on the
external surfaces of the zygomatic arches, for measuring the IA the external width of the ala of …