Background In 2010, overweight and obesity were estimated to cause 3·4 million deaths, 3·9%
of years of life lost, and 3·8% of disability-adjusted life-years (DALYs) worldwide. The rise …

Importance Cancer is the second leading cause of death worldwide. Current estimates on
the burden of cancer are needed for cancer control planning. Objective To estimate mortality, …

Background Non-fatal outcomes of disease and injury increasingly detract from the ability of
the world's population to live in full health, a trend largely attributable to an epidemiological …

Background Up-to-date evidence about levels and trends in disease and injury incidence,
prevalence, and years lived with disability (YLDs) is an essential input into global, regional, …

Background As mortality rates decline, life expectancy increases, and populations age, non-fatal
outcomes of diseases and injuries are becoming a larger component of the global …

Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides
an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden …

Background Improving survival and extending the longevity of life for all populations requires
timely, robust evidence on local mortality levels and trends. The Global Burden of Disease …

Background Alcohol use is a leading risk factor for death and disability, but its overall association
with health remains complex given the possible protective effects of moderate alcohol …

Importance Cancer is among the leading causes of death worldwide. Current estimates of
cancer burden in individual countries and regions are necessary to inform local cancer control …

<p id="p001">Early-onset, severe retinal dystrophy caused by mutations in the gene encoding
retinal pigment epithelium–specific 65-kD protein (<italic>RPE65</italic>) is associated …