The cytochrome P450s (CYPs) constitute a superfamily of isoforms that play an important role
in the oxidative metabolism of drugs. Each CYP isoform possesses a characteristic broad …

Drug research encompasses several diverse disciplines united by a common goal, namely
the development of novel therapeutic agents. The search for new drugs can be divided …

The glutathione S-transferases (GSTs) are a family of proteins that conjugate glutathione on
the sulfur atom of cysteine to various electrophiles (1-5). In addition, GST binds with high …

An enzyme system which catalyzes the ω-hydroxylation of fatty acids in the presence of
reduced triphosphopyridine nucleotide and molecular oxygen has been obtained in a soluble …

The enzyme system in liver microsomes which catalyzes the ω-hydroxylation of fatty acids in
the presence of molecular oxygen and a reduced pyridine nucleotide has been solubilized …

Individual variability in drug efficacy and drug safety is a major challenge in current clinical
practice, drug development, and drug regulation. For more than 5 decades, studies of …

Drug interactions have always been a major concern in medicine for clinicians and patients.
Inhibition and induction of cytochrome P450 (CYP) enzymes are probably the most common …

CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic
aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, …

Testosterone, terfenadine, midazolam, and nifedipine, four commonly used substrates for
human cytochrome P-450 3A4 (CYP3A4), were studied in pairs in human liver microsomes …

The environmental effects and fate of ivermectin were studied either as the pure compound
or in feces. Toxicities to microbes, earthworms, algae, fish, and Daphnia, soil-binding …