PURPOSE OF REVIEW This article is an update from the article on antiepileptic drug (AED)
therapy published in the last Continuum issue on epilepsy and is intended to cover the vast …

… in the February 2016 Epilepsy issue of Continuum: Lifelong Learning in Neurology as “Antiepileptic
Drugs,” and at the request of the Editor-in-Chief was updated by Dr Abou-Khalil for …

Purpose: Sudden unexpected death in epilepsy (SUDEP) is a major cause of mortality for
patients with epilepsy. Cardiac factors may be involved and were evaluated in this study. …

Objective: To evaluate the efficacy and safety of ezogabine (United States adopted name)/retigabine
(international nonproprietary name) (EZG[RTG]) 1,200 mg/day as adjunctive …

The incidence of new-onset epilepsy is high among elderly patients. Seizures can present
differently to and with more subtle semiology than those in younger adults. This difference in …

Objective Currently, approximately 60–70% of patients with unilateral temporal lobe epilepsy
(TLE) remain seizure‐free 3 years after surgery. The goal of this work was to develop a …

Positron emission tomography (PET) performed with { 18 F}‐2‐fluoro‐2‐deoxy‐D‐glucose ({
18 F}FDG) was used to measure local cerebral metabolic rate for glucose (lCMRGlc) …

Objective Seizures in temporal lobe epilepsy (TLE) disturb brain networks and lead to
connectivity disturbances. We previously hypothesised that recurrent seizures in TLE may lead to …

Purpose: To examine postictal breathing pattern in generalized convulsive nonepileptic
seizures (GCNES) and generalized tonic–clonic seizures (GTCS) and evaluate this feature as a …

Purpose: A double‐blind, randomized, placebo‐controlled clinical trial to examine the safety,
tolerability, and antiepileptic activity of ganaxolone in patients after withdrawal from other …