Gene therapy has emerged as a promising therapeutic strategy for various conditions,
including blood disorders, ocular disease, cancer, and nervous system disorders. The advent of …

Aim Previous studies demonstrated the neuroprotective effects of testosterone, but no previous
study has examined the neuroprotective effects of testosterone on spinal cord ischemia/…

Background The development of secondary brain injury via oxidative stress after traumatic
brain injury (TBI) is well known. Decorin (DC) inactivates transforming growth factor β1, …

Background Darbepoetin-alpha (DA) is a novel erythropoiesis-stimulating agent developed
for treating anemia. In animal models, recombinant human erythropoietin has been reported …

Methotrexate was developed as a cytostatic agent, but at low doses, it has shown potent anti-inflammatory
activity. Previous studies have demonstrated that the anti-inflammatory effects …

Objective Dexpanthenol (DXP) reportedly protects tissues against oxidative damage in
various inflammation models. This study aimed to evaluate its effects on oxidative stress, …

Results After ischemia-reperfusion injury, increments were found in the tissue myeloperoxidase
levels (p< 0.001), malondialdehyde levels (p< 0.001), xanthine oxidase action (p< 0.001…

Background The agent, 2-mercaptoethane sulfonate (MESNA), is a synthetic small molecule,
widely used as a systemic protective agent against chemotherapy toxicity, but is primarily …

Objective Previous studies have shown niacin has neuroprotective effects on the central
nervous system. However, its specific effect on spinal cord ischemia/reperfusion injury has not …

Results: Following trauma both glutathione peroxidase, superoxide dismutase levels decreased
(p< 0.001 for both); darbepoetin-α increased the activity of both antioxidant enzymes (p= …