• Positron emission tomography and selective radioligands were used to determine D , and
D 2 dopamine receptor occupancy induced by neuroleptics in the basal ganglia of drug-…

Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts
as a gatekeeper to control the passage and exchange of molecules and nutrients between …

• Using positron emission tomography and the carbon 11—labeled ligand raclopride, central
D2-dopamine receptor occupancy in the putamen was determined in psychiatric patients …

OBJECTIVE: The study examined the influence of losses in dopaminergic function on age-related
cognitive deficits. METHOD: Eleven healthy subjects (21–68 years of age) completed …

The relationship between central D2-dopamine receptor occupancy and antipsychotic drug
effects was examined in a double-blind study. Raclopride was the compound used to induce …

Densities and distribution of D 1-dopamine and D 2-dopamine receptors were investigated
in vitro using [3 H] SCH 23390 and [3 H] raclopride in receptor binding assays and …

• Several groups have reported increased densities of D 2 dopamine receptors in the basal
ganglia of schizophrenic brains postmortem. The significance of this finding has been …

Several neurochemical in vitro and in vivo imaging studies have been aimed at characterizing
the localization of serotonin receptors and transporters in the human brain. In this study, a …

Objective: Central D,, D2, and 5-HT2 receptor occupancy in schizophrenic patients treated
with clozapine was determined and related to clozapine serum concentrations. Method: …

We examined the relationship of age-related losses of striatal dopamine transporter (DAT)
density to age-related deficits in episodic memory and executive functioning in a group of …