Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of fundamentally
different diseases with different histologic, genomic, and immunologic profiles, which are …

Mainly known for its role in peripheral glucose homeostasis, insulin has also significant impact
within the brain, functioning as a key neuromodulator in behavioral, cellular, biochemical …

High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability 1
, 2 , 3 – 4 patterned by distinct mutational processes 5 , 6 , tumour heterogeneity 7 , 8 – 9 …

As blood oxygenation decreases (hypoxemia), mammals mount cardiorespiratory responses,
increasing oxygen to vital organs. The carotid bodies are the primary oxygen …

Tall cell carcinoma with reverse polarity is a rare subtype of breast carcinoma with solid and
papillary growth and nuclear features reminiscent of those of the tall cell variant of papillary …

Key points Activity‐dependent plasticity can be induced in carotid body (CB) chemosensory
afferents without chronic intermittent hypoxia (CIH) preconditioning by acute intermittent …

Purpose Previous studies indicate that breast cancer molecular subtypes differ with respect
to their dependency on autophagy, but our knowledge of the differential expression and …

Here, we demonstrate that mosaic variants in CSGs arising in early embryogenesis contribute
to the oncogenesis of seemingly sporadic cancers. These variants can be systematically …

Clear cell carcinoma (CCC) of the cervix (cCCC) is a rare and aggressive type of human
papillomavirus (HPV)‐negative cervical cancer with limited effective treatment options for …

Background: Germline genetic alterations are established mediators of breast carcinogenesis,
often giving rise to specific forms of genomic instability. BRCA1/2 pathogenic variants (PVs…