T-cells are crucial in maintanence of intestinal homeostasis, however, it is still unclear how
microbiota metabolites regulate T-effector cells. Here we show gut microbiota-derived short-…

It has been shown recently that neutrophils are able to produce IL-22 and IL-17, which
differentially regulate the pathogenesis of inflammatory bowel disease. However, it is still largely …

The antimicrobial peptides (AMP) produced by intestinal epithelial cells (IEC) play crucial
roles in the regulation of intestinal homeostasis by controlling microbiota. Gut microbiota has …

Highlights • Microbial metabolites are increasingly recognized as a functional output of the
microbiome that impacts both host physiology and immunity. • A broad array of components of …

Intestinal IgA, which is regulated by gut microbiota, has a crucial role in maintenance of intestinal
homeostasis and in protecting the intestines from inflammation. However, the means by …

Multiple mechanisms are involved in regulation of host response to microbiota to maintain
the intestinal homeostasis. Th17 cells are enriched in the intestinal lamina propria under …

Background Neutrophils are accumulated in inflamed mucosa of IBD and play an important
role in the pathogenesis. CD177 is expressed in neutrophils specifically and upregulated …

The colonic epithelium can undergo multiple rounds of damage and repair, often in response
to excessive inflammation. The responsive stem cell that mediates this process is unclear, …

There is a major unmet clinical need to identify pathways in inflammatory bowel disease (IBD)
to classify patient disease activity, stratify patients that will benefit from targeted therapies …

The gut microbiota has been shown critical for mucosal adjuvant activity of cholera toxin (CT),
a potent mucosal adjuvant. However, the mechanisms involved remain largely unknown. …