Prelingual non-syndromic (isolated) deafness is the most frequent hereditary sensory defect.
In >80% of the cases, the mode of transmission is autosomal recessive. To date, 14 loci …

Hereditary non-syndromic profound deafness affects about 1 in 2000 children prior to language
acquisition. In 80% of the cases, the mode of transmission is autosomal recessive. The …

Usher syndrome type I (USH1) is the most frequent cause of hereditary deaf–blindness in
humans. Seven genetic loci (USH1A-G) have been implicated in this disease to date, and four …

Diabetic nephropathy (DN) develops in a large number of type 1 (T1D) and type 2 diabetic (T2D)
patients after a variable latency period. DN absolute number is increasing because of …

Introduction The majority of autoimmune diseases such as rheumatoid arthritis (RA) and
autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance …

Angle-closure glaucoma (ACG) is a subset of glaucoma affecting 16 million people 1 , 2 , 3 .
Although 4 million people are bilaterally blind from ACG 4 , 5 , the causative molecular …

Vitamin D is a potent regulator of calcium homeostasis and may have immunomodulatory
effects. The influence of vitamin D on human autoimmune disease is controversial. The aim of …

Deafness is an important health problem in the Tunisian population, especially in isolates
where the prevalence ranges from 2 to 8%. To evaluate the effect of inbred unions on deafness…

More and more patients worldwide suffer from end-stage renal disease which often is secondary
to diabetes (eg 36.9% of all US patients with end-stage renal disease have a diabetic …

Usher syndrome (USH) is a clinically and genetically heterogeneous disorder characterized
by congenital hearing loss combined with retinitis pigmentosa. This dual sensorineural …