Objective: This study assessed the efficacy of olanzapine in delaying or preventing
conversion to psychosis and reducing symptoms in people with prodromal symptoms of …

BACKGROUND: There has been increasing interest in early detection during the prodromal
phase of a psychotic disorder. To date a few treatment studies have been published with …

Research suggests that Intolerance of Uncertainty (IU) is related to the severity of suffering
in Generalized Anxiety Disorder (GAD). However, its role in Social Anxiety Disorder (SAD) …

Background: It has been suggested that transiently high dopamine-2 (D2) receptor occupancy
by antipsychotic medication may be sufficient for inducing an antipsychotic response. We …

BACKGROUND: In much of the world, general practitioners (GPs) are the health professionals
most frequently initially contacted when a young person is developing psychosis. …

Aim: In early detection work, recruiting individuals who meet the prodromal criteria is difficult.
The aim of this paper was to describe the development of a research clinic for individuals …

Background The burdens imposed by treatment-resistant depression (TRD) necessitate the
identification of predictive factors that may improve patient treatment and outcomes. Because …

Background: Typically, studies investigating those at clinical high risk for psychosis have
focused on predictors of conversion and treatments that might prevent conversion to full‐blown …

Major depressive disorder (MDD) is a highly prevalent chronic psychiatric illness associated
with significant morbidity, mortality, loss of productivity, and diminished quality of life. …

Objective: Response to typical antipsychotic medication has been associated with achieving
a level of striatal dopamine D 2 receptor occupancy in the range of 65% to 70%. We …