Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions
with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes …

… Author links open overlay panel Ulf Lindahl , Jin‐ping Li … deduced from structural analysis
of HS generated by mutant embryos (Li et al., 2003, Merry et al., 2001, Ringvall et al., 2000). …

Heparan sulfate (HS) proteoglycans at the cell surface and in the extracellular matrix of
most animal tissues are essential in development and homeostasis, and are implicated in …

Extracellular vesicle (EV)-mediated intercellular transfer of signaling proteins and nucleic
acids has recently been implicated in the development of cancer and other pathological …

Heparan sulfate proteoglycans, attached to cell surfaces or in the extracellular matrix, interact
with a multitude of proteins via their heparan sulfate side chains. Degradation of these …

When shed from the cell surface, the heparan sulfate proteoglycan syndecan-1 can facilitate
the growth, angiogenesis, and metastasis of tumors. Here we report that tumor cell …

On March 11, 2020, the World Health Organization declared its assessment of coronavirus
disease 2019 (COVID‐19) as a global pandemic. However, specific anti‐severe acute …

During infection, chemokines sequestered on endothelium induce recruitment of circulating
leukocytes into the tissue where they chemotax along chemokine gradients toward the …

One of the key regulators of endochondral ossification is Indian hedgehog (Ihh), which acts
as a long-range morphogen in the developing skeletal elements. Previous studies have …

Using a high throughput heparan sulfate (HS) isolation and characterization protocol, we
have analyzed HS structure in several tissues from mice/mouse embryos deficient in HS …