Intracerebroventricular injection of orexin-A (hypocretin-1) has been shown to elicit the
analgesic responses. However, the locations of central sites that may mediate these effects have …

Alzheimer's disease (AD) is characterized by the formation of amyloid beta (Aβ) plaques in
the brain. Dysfunctional excitatory synaptic transmission and neuronal plasticity are generally …

It has been shown that orexin neuropeptides contribute to morphine-induced physical
dependence. The locus coeruleus (LC), which receives a dense extra-hypothalamic orexinergic …

Recent studies have suggested the involvement of some metabolic hormones in memory
formation and synaptic plasticity. Insulin dysfunction is known as an essential process in the …

Depression is a devastating mood disorder affecting more than 300 million people worldwide.
Almost 30 % of patients still suffer from treatment resistant depression. Although many …

Adiponectin (APN) plays a major role in the regulation of insulin sensitivity and glucose
homeostasis. Insulin and APN have a positive effect on memory. In this study, we examined …

… K Rohampour and E Sharifipour designed the study protocol. SA Hejazi contributed to the
conduction of the study, and interpretation of the results. S Sharifimoghadam, N Hassanzadeh, …

Peripheral nerve injury (PNI) is believed to cause maladaptive changes at synaptic level,
leading to neuropathic pain which is difficult to treat with common analgesic drugs. …

Herein the effect of hippocampal orexin type-1 receptors (OX1Rs) blockade on morphine
withdrawal syndrome was studied. Animals were made dependent by subcutaneous (sc) …

Depression is a series of symptoms that influence mood, thinking, and behavior and create
unpleasant emotions like hopelessness and apathy. Treatment-resistant depression (TRD) …