purpose. Primary open-angle glaucoma (POAG) is the second most common cause of
blindness. It has been linked to mutations in the myocilin (MYOC) and optineurin (OPTN) genes, …

Complex I (NADH:ubiquinone oxidoreductase) is the first and largest multimeric complex of
the mitochondrial respiratory chain. Human complex I comprises seven subunits encoded by …

Background Genetic studies of the Arabian Peninsula are scarce even though the region
was the center of ancient trade routes and empires and may have been the southern corridor …

Nuclear genetic disorders causing mitochondrial DNA (mtDNA) depletion are clinically and
genetically heterogeneous, and the molecular etiology remains undiagnosed in the majority …

Resveratrol, a naturally occurring plant polyphenol found in grapes, is the principal biologically
active component in red wine. Clinical studies have shown that resveratrol due to its …

Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex
disease with a significant genetic contribution. We performed Exome Array (Illumina) …

Exfoliation syndrome (XFS) is the most common recognizable cause of open-angle
glaucoma worldwide. To better understand the etiology of XFS, we conducted a genome-wide …

Background Human origins and migration models proposing the Horn of Africa as a
prehistoric exit route to Asia have stimulated molecular genetic studies in the region using …

Keratoconus is a progressive thinning and anterior protrusion of the cornea that results in
steepening and distortion of the cornea, altered refractive powers, and reduced vision. …

Background Two potential migratory routes followed by modern humans to colonize Eurasia
from Africa have been proposed. These are the two natural passageways that connect both …