Precision medicine focuses on DNA abnormalities, but not all tumors have tractable genomic
alterations. The WINTHER trial ( NCT01856296 ) navigated patients to therapy on the basis …

The targeting of RNA for the design of novel anti-viral compounds represents an area of
vast potential. We have used NMR and computational methods to model the interaction of a …

* Abstract Opinion formation and innovation diffusion have gained lots of attention in the last
decade due to its application in social and political science. Control of the diffusion process …

We report the design and validation of a fast empirical function for scoring RNA-ligand
interactions, and describe its implementation within RiboDock®, a virtual screening system for …

The targeting of RNA for the design of novel anti-viral compounds has until now proceeded
largely without incorporating direct input from structure-based design methodology, partly …

This study proposes a novel socio-hydrological modeling framework for assessing the
performance of complex water resources systems. It employs and integrates agent-based …

One of the new methods that can be used to study the thermodynamics, critical points of a
system based on a topological approach is the study of topological charges using Duan’s ϕ -…

Developing a general framework to capture the complexities associated with the non-linear
and adaptive nature of farmers facing water resources scarcity is a challenging problem. This …

Three-dimensional (3D) in vitro models of human skeletal muscle mimic aspects of native
tissue structure and function, thereby providing a promising system for disease modeling, drug …

In this paper, we use the generalized off-shell Helmholtz free energy method to explore the
thermodynamic properties of Bardeen black holes (BD BHs) from a topological perspective …