The emergence of the novel SARS coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), has resulted in an unprecedented pandemic that has …

Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols.
Severe side effects such as cardiotoxicity, however, limit Dox application. Mechanisms by …

Background: The human heart primarily metabolizes fatty acids, and this decreases as
alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with …

Doxorubicin (Dox), a widely used chemotherapy drug, can also cause cardiotoxic effects
leading to heart failure. The excessive oxidative stress caused by Dox results in the …

Temozolomide (TMZ) is a chemotherapy agent used to treat Grade IV astrocytoma, also
known as glioblastoma (GBM). TMZ treatment causes DNA damage that results in tumor cell …

Iron plays an important role in mammalian physiological processes. It is a critical
component for the function of many proteins, including enzymes that require heme and iron-sulfur …

Fibroblast growth factor 2 (FGF-2) is a multifunctional protein synthesized as high (Hi-) and
low (Lo-) molecular weight isoforms. Studies using rodent models showed that Hi- and Lo-…

Objective To evaluate the effect of metformin treatment on the risperidone-induced body
weight gain in patients. Methods In a 12-weeks, double-blind, placebo controlled, randomized …

We have previously shown that overexpression of SKI, an endogenous TGF-β 1 repressor,
deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now show that SKI also …

MTORC1 integrates signaling from the immune microenvironment to regulate T cell activation,
differentiation, and function. TSC2 in the tuberous sclerosis complex tightly regulates …