Mutations of PKD1 and PKD2 account for 85 and 15% of cases of autosomal dominant
polycystic kidney disease (ADPKD), respectively. Clinically, PKD1 is more severe than PKD2, …

Background & Aims Constipation is a common clinical problem that negatively impacts quality
of life and is associated with significant health care costs. Activation of the cystic fibrosis …

Glomerular disease is a common cause for proteinuria and chronic kidney disease leading
to end-stage renal disease requiring dialysis or kidney transplantation in children. Nephrotic …

Diarrhea is a major side effect of ErbB receptor tyrosine kinase inhibitors (TKIs) in cancer
chemotherapy. Here, we show that the primary mechanism of ErbB TKI diarrhea is activation of …

Pendrin is a Cl−/HCO 3− exchanger expressed in type B and non-A, non-B intercalated cells
in the distal nephron, where it facilitates Cl− absorption and is involved in Na+ absorption …

Secretory diarrheas caused by bacterial enterotoxins, including cholera and traveler’s
diarrhea, remain a major global health problem. Inappropriate activation of the cystic fibrosis …

Cyclic nucleotide elevation in intestinal epithelial cells is the key pathology causing intestinal
fluid loss in secretory diarrheas such as cholera. Current secretory diarrhea treatment is …

Background Congenital nephrotic syndrome (CNS) and infantile nephrotic syndrome (INS)
are caused primarily by mutations in genes that encode structural and regulatory proteins of …

SLC26A3 (downregulated in adenoma; DRA) is a Cl–/anion exchanger expressed in the
luminal membrane of intestinal epithelial cells, where it facilitates electroneutral NaCl …

Transmembrane protein 16A (TMEM16A), also called anoctamin 1 (ANO1), is a calcium-activated
chloride channel expressed widely mammalian cells, including epithelia, vascular …