Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23
susceptibility loci thus far. Analyses of previously conducted GWAS indicate additional risk loci …

Objective The pathologic basis of systemic juvenile idiopathic arthritis (JIA) is a subject of
some controversy, with evidence for both autoimmune and autoinflammatory etiologies. …

Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity
with the underlying genetic composition, particularly in genes encoding for protein factors …

Background/Aims: HBV-related chronic liver disease patients often present with hepatic
decompensation and are not eligible for interferon therapy. Whether long-term lamivudine is …

Background While dietary fat has been established as a risk factor for colorectal cancer (CRC),
associations between fatty acids (FAs) and CRC have been inconsistent. Using …

While elevated blood cholesterol has been associated with an increased risk of colorectal
cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian …

Background: Observational studies have associated adiposity with an increased risk of
colorectal cancer (CRC). However, such studies do not establish a causal relationship. To …

Background Multiple loci have been identified for coronary artery disease (CAD) by genome-wide
association studies (GWAS), but no such studies on CAD incidence has been reported …

Purpose: Dysmorphology syndromes are among the most common referrals to clinical genetics
specialists. Inability to match the dysmorphology pattern to a known syndrome can pose …

Nonsense-mediated decay (NMD) is an important process that is best known for degrading
transcripts that contain premature stop codons (PTCs) to mitigate their potentially harmful …