Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse
Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively
extends the progression-free survival of breast, lung, and ovarian cancer patients. However, …
extends the progression-free survival of breast, lung, and ovarian cancer patients. However, …
[HTML][HTML] The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management
…, ME Ibrahim, SS Alqahtani, SD AlSharari… - Frontiers in …, 2019 - frontiersin.org
Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having
immuno-modulating properties. This bacterium is an example of a microorganism inducing …
immuno-modulating properties. This bacterium is an example of a microorganism inducing …
[HTML][HTML] Effects of menthol on nicotine pharmacokinetic, pharmacology and dependence in mice
SD Alsharari, JR King, JC Nordman, PP Muldoon… - PloS one, 2015 - journals.plos.org
Although menthol, a common flavoring additive to cigarettes, has been found to impact the
addictive properties of nicotine cigarettes in smokers little is known about its pharmacological …
addictive properties of nicotine cigarettes in smokers little is known about its pharmacological …
The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor
The α7 nicotinic acetylcholine receptor (nAChR) is a promising drug target for a number of
neurological disorders including chronic pain and inflammatory diseases. Since α7 can …
neurological disorders including chronic pain and inflammatory diseases. Since α7 can …
Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice
SD AlSharari, K Freitas, MI Damaj - Biochemical pharmacology, 2013 - Elsevier
A growing body of evidence indicates that α7 nicotinic receptor subtypes play an important
role in chronic inflammatory and neuropathic pain signaling. In the present study, we …
role in chronic inflammatory and neuropathic pain signaling. In the present study, we …
Antinociceptive properties of 25‐methoxy hispidol A, a triterpinoid isolated from Poncirus trifoliata (Rutaceae) through inhibition of NF‐κB signalling in mice
The 25‐methoxy hispidol A (25‐MHA) is a triterpenoid, isolated from the immature fruit of
Poncirus trifoliata (Rutaceae). The pretreatment with 25‐MHA markedly (p < 0.001) attenuated …
Poncirus trifoliata (Rutaceae). The pretreatment with 25‐MHA markedly (p < 0.001) attenuated …
The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain
D Bagdas, SD AlSharari, K Freitas, M Tracy… - Biochemical …, 2015 - Elsevier
… Author links open overlay panel Deniz Bagdas a b 1 , Shakir D. AlSharari a c 1 , Kelen …
Effect of carrageenan on TNF-α paw levels (D) at 6 h after intraplantar injection of carrageenan in …
Effect of carrageenan on TNF-α paw levels (D) at 6 h after intraplantar injection of carrageenan in …
[HTML][HTML] Effect of 25-methoxy hispidol A isolated from Poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative …
Neuroinflammation, oxidative stress and apoptosis are implicated in the pathogenesis of
neuropsychiatric diseases like anxiety and depression. 25-Methoxyhispidol A (25-MHA) is a …
neuropsychiatric diseases like anxiety and depression. 25-Methoxyhispidol A (25-MHA) is a …
Plasticizer, di (2-ethylhexyl) phthalate (DEHP) enhances cockroach allergen extract-driven airway inflammation by enhancing pulmonary Th2 as well as Th17 immune …
…, NO Al-Harbi, MM Al-Harbi, SD AlSharari - Environmental …, 2018 - Elsevier
In recent decades, there has been a gradual increase in the prevalence of asthma. Various
factors including environmental pollutants have contributed to this phenomenon. Plasticizer, …
factors including environmental pollutants have contributed to this phenomenon. Plasticizer, …
[HTML][HTML] Rutin attenuates Hepatotoxicity in high-cholesterol-diet-fed rats
SD AlSharari, SS Al-Rejaie, HM Abuohashish… - … Medicine and Cellular …, 2016 - hindawi.com
Background and Objective. High-cholesterol diet (HCD) intends to increase the oxidative
stress in liver tissues inducing hepatotoxicity. Rutin is a natural flavonoid (vitamin p) which is …
stress in liver tissues inducing hepatotoxicity. Rutin is a natural flavonoid (vitamin p) which is …