User profiles for Shanmugakonar Muralitharan

Muralitharan Shanmugakonar

Laboratory Manager, Laboratory Animal Research Centre, Qatar University
Verified email at qu.edu.qa
Cited by 1130

[HTML][HTML] Tight junction proteins and signaling pathways in cancer and inflammation: a functional crosstalk

…, S Hashem, SK Yadav, M Shanmugakonar… - Frontiers in …, 2019 - frontiersin.org
The ability of epithelial cells to organize through cell–cell adhesion into a functioning
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent …

RAS-mediated oncogenic signaling pathways in human malignancies

…, KS Siveen, KS Prabhu, M Shanmugakonar… - Seminars in cancer …, 2019 - Elsevier
Abnormally activated RAS proteins are the main oncogenic driver that governs the
functioning of major signaling pathways involved in the initiation and development of human …

[HTML][HTML] Claudin-1, a double-edged sword in cancer

…, SK Yadav, R Krishnankutty, S Muralitharan… - International journal of …, 2020 - mdpi.com
Claudins, a group of membrane proteins involved in the formation of tight junctions, are
mainly found in endothelial or epithelial cells. These proteins have attracted much attention in …

[HTML][HTML] Chronic cadmium exposure alters cardiac matrix metalloproteinases in the heart of Sprague-Dawley rat

SC Das, K Varadharajan, M Shanmugakonar… - Frontiers in …, 2021 - frontiersin.org
The aim of this study was to evaluate the role of chronic cadmium exposure in modulating
cardiac matrix metalloproteinases (MMPs) in the heart of rats. Adult male Sprague-Dawley rats …

[HTML][HTML] Cadmium: An emerging role in adipose tissue dysfunction

SM Attia, K Varadharajan, M Shanmugakonar… - Exposure and …, 2022 - Springer
Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial
anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd …

Absence of deafness‐associated connexin‐26 (GJB2) gene mutations in the Omani population

…, N Al‐Wardy, A Al‐Khayat, M Shanmugakonar… - Human …, 2001 - Wiley Online Library
We have investigated the prevalence of mutations in the connexin 26 (GJB2) gene in Omani
population using both PCR‐RFLP and direct DNA sequencing methods. Two common …

[HTML][HTML] NF-κB essential modulator (NEMO) is critical for thyroid function

…, M Zannini, T de Cristofaro, M Shanmugakonar… - Journal of Biological …, 2016 - ASBMB
The I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for
canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, …

Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

…, R Al-Mjeni, C Li, S Muralitharan… - Pediatric hematology …, 2005 - Taylor & Francis
Gene expression profiling may improve the understanding of the biology behind relapse in
pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), …

Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia

A Hempelmann, S Kumar, S Muralitharan, T Sander - Neuroscience letters, 2006 - Elsevier
Two recurrent missense mutations (c.20C>T: A7V; c.26C>T: A9V) in the gene encoding the
myofibrillogenesis regulator 1 (MR-1) have been shown to cause autosomal dominant …

Novel spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis in ethnic Omani patients

S Muralitharan, YA Wali, D Dennison… - American journal of …, 2007 - Wiley Online Library
Familial hemophagocytic lymphohistiocytosis (FHL) is an autosomal recessive immune
disorder, characterized by fever, hepatosplenomegaly, pancytopenia, hypertriglyceridemia, …