[HTML][HTML] Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing

S Chen, Y Zhu, Q Xu, Q Jiang, D Chen, T Chen… - Nature …, 2022 - nature.com
High-glucose microenvironment in the diabetic foot ulcer (DFU) causes excessive glycation
and induces chronic inflammation, leading to the difficulty of DFU healing. Hydrogen-rich …

Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential

WW Min, CJ Yuskaitis, Q Yan, C Sikorski, S Chen… - …, 2009 - Elsevier
Significant advances have been made in understanding the underlying defects of and
developing potential treatments for Fragile X syndrome (FXS), the most common heritable mental …

An Akkermansia muciniphila subtype alleviates high-fat diet-induced metabolic disorders and inhibits the neurodegenerative process in mice

…, Z Ou, D Wu, L Deng, Z Lu, J Zhang, G Deng, S Chen… - Anaerobe, 2020 - Elsevier
The prevalence of obesity and diabetes, and their complicating mental disorders, severely
affect public health. This study aimed to investigate the long-term effects of an Akkermansia …

Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing

Q Xu, S Chen, L Jiang, C Xia, L Zeng… - National Science …, 2023 - academic.oup.com
It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases
because dense extracellular polymeric substance matrix prevents routine antibacterial agents …

[HTML][HTML] Local H2 release remodels senescence microenvironment for improved repair of injured bone

S Chen, Y Yu, S Xie, D Liang, W Shi, S Chen… - Nature …, 2023 - nature.com
The senescence microenvironment, which causes persistent inflammation and loss of intrinsic
regenerative abilities, is a main obstacle to effective tissue repair in elderly individuals. In …

Two‐Dimensional Mg2Si Nanosheet‐Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin

…, D Chen, Q Xu, J Chen, Y Zeng, S Chen… - Advanced …, 2023 - Wiley Online Library
Molecular hydrogen holds a high potential for wound healing owing to its anti‐inflammatory
effect and high biosafety, but commonly used hydrogen administration routes hardly achieve …

Inhibition of free heme-catalyzed Fenton-like reaction prevents non-alcoholic fatty liver disease by hepatocyte-targeted hydrogen delivery

M Zhao, Z Jin, C Xia, S Chen, L Zeng, S Qin, Q He - Biomaterials, 2023 - Elsevier
The metabolic disorder of hepatocytes in non-alcoholic fatty liver disease (NAFLD) leads to
the formation of an iron pool which induces the Fenton reaction-derived ferroptosis and the …

Glutathione/pH-responsive copper-based nanoplatform for amplified chemodynamic therapy through synergistic cycling regeneration of reactive oxygen species and …

S Jia, S Ke, L Tu, S Chen, B Luo, Y Xiong, Y Li… - Journal of Colloid and …, 2023 - Elsevier
The rapid scavenging of reactive oxygen species (ROS) by glutathione (GSH) and insufficient
endogenous hydrogen peroxide (H 2 O 2 ) in tumor cells are the major factors greatly …

[HTML][HTML] Foxp3 (−/ATT) Polymorphism Contributes to the Susceptibility of Preeclampsia

X Chen, T Gan, Z Liao, S Chen, J Xiao - PloS one, 2013 - journals.plos.org
Objective To evaluate the potential influence of Foxp3 polymorphism on preeclampsia (PE)
susceptibility, we conducted a case-control study in Han Chinese women. Methods Foxp3 …

[HTML][HTML] Association of transforming growth factor-β1 gene C-509T and T869C polymorphisms with atherosclerotic cerebral infarction in the Chinese: a case-control …

Z Peng, L Zhan, S Chen, E Xu - Lipids in health and disease, 2011 - Springer
Background Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine involved
in inflammation and pathogenesis of atherosclerosis. There is scant information on the …