[HTML][HTML] miRNAs: biological and clinical determinants in epilepsy

WA Alsharafi, B Xiao, MM Abuhamed… - Frontiers in molecular …, 2015 - frontiersin.org
Recently, microRNAs (miRNAs) are reported to be crucial modulators in the pathogenesis
and potential treatment of epilepsies. To date, several miRNAs have been demonstrated to be …

Micro RNA‐139‐5p negatively regulates NR 2A‐containing NMDA receptor in the rat pilocarpine model and patients with temporal lobe epilepsy

WA Alsharafi, B Xiao, J Li - Epilepsia, 2016 - Wiley Online Library
Objectives Regulation of N‐methyl‐d‐aspartate ( NMDA ) subunits NR 2A and NR 2B
expression during status epilepticus ( SE ) remains incompletely understood. Here we explored …

Correlation between IL-10 and microRNA-187 expression in epileptic rat hippocampus and patients with temporal lobe epilepsy

WA Alsharafi, B Xiao, MM Abuhamed, FF Bi… - Frontiers in Cellular …, 2015 - frontiersin.org
Accumulating evidence is emerging that microRNAs (miRNAs) are key regulators in controlling
neuroinflammatory responses that are known to play a potential role in the pathogenesis …

MicroRNA in glutamate receptor-dependent neurological diseases

WA Alsharafi, Z Luo, X Long, Y Xie, B Xiao - Clinical Science, 2017 - portlandpress.com
Glutamate-mediated excitotoxicity is the major neuropathological process contributing to
numerous neurological diseases. Recently, emerging evidence indicates that microRNAs (…

Effect of Khat on apoptosis and related gene Smac/DIABLO expression in the cerebral cortex of rats following transient focal ischemia

WA Alsharafi, F Bi, Y Hu, HM Mujlli, B Xiao - Environmental toxicology and …, 2015 - Elsevier
Background The leaves of the Khat shrub contain the major alkaloid compounds (cathinone)
and cathine. These compounds can induce apoptosis and exacerbate the acute cerebral …

Dynamic expression of microRNAs (183, 135a, 125b, 128, 30c and 27a) in the rat pilocarpine model and temporal lobe epilepsy patients

W Alsharafi, B Xiao - … (Formerly Current Drug Targets-CNS & …, 2015 - ingentaconnect.com
Recently, microRNAs (miRNAs) are emerging as new regulators in the pathogenesis of
temporal lobe epilepsy (TLE) and playing a major role in the inflammatory and immune …

Changes in the numbers and distribution of calretinin in the epileptic rat hippocampus

MM Abuhamed, X Bo, WA Alsharafi, L Jing… - Neurosciences …, 2010 - nsj.org.sa
OBJECTIVE: To examine calretinin (CR)-containing interneurons that degenerate in the
hippocampus in post status epilepticus (SE) rats at different time points. METHODS: This study …

A detector generating algorithm for intrusion detection inspired by artificial immune system

WM Alsharafi, MN Omar - ARPN Journal of Engineering and …, 2015 - repo.uum.edu.my
Artificial immune system (AIS) allows us to inspire several ideas for the design of computer
intrusion detection.The standard of negative selection algorithm (NSA), offered by Stephanie …

Normal Profile Updating Method for Enhanced Packet Header Anomaly Detection

WM Alsharafi, MN Omar, NA Al-Majmar… - Emerging Trends in …, 2020 - Springer
There is a significant need for various Intrusion Detection Systems (IDS) methods for packet
behavior anomaly detection, due to the consistent exposure of packets to frequent intrusion …

[PDF][PDF] A Normal Profile Updating Method for False Positives Reduction in Anomaly Detection Systems

WM Alsharafi, MN Omar - academia.edu
The contribution of this paper is to investigate whether there is a possibility of further processing
of both the normal and abnormal data identified by any anomaly detector with the intent …