Gene regulation and DNA damage in the ageing human brain
The ageing of the human brain is a cause of cognitive decline in the elderly and the major risk
factor for Alzheimer's disease 1 . The time in life when brain ageing begins is undefined 2 , …
factor for Alzheimer's disease 1 . The time in life when brain ageing begins is undefined 2 , …
Multicomponent isoreticular metal-organic frameworks: Principles, current status and challenges
The Multicomponent Isoreticular Metal-Organic Frameworks (MI-MOFs) are the materials
designed either with multiple linkers or mixed-metals as secondary building units (SBUs). …
designed either with multiple linkers or mixed-metals as secondary building units (SBUs). …
REST and stress resistance in ageing and Alzheimer's disease
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve
function and protect against neurodegeneration during ageing are unknown. Here we show that …
function and protect against neurodegeneration during ageing are unknown. Here we show that …
Recent developments in luminescent coordination polymers: Designing strategies, sensing application and theoretical evidences
The designing, characterization and utility of luminescent coordination polymers as sensors
to detect molecules and ions, constitute an active area of research. Further, theoretical …
to detect molecules and ions, constitute an active area of research. Further, theoretical …
Retention of heroin and morphine–6β–glucuronide analgesia in a new line of mice lacking exon 1 of MOR–1
Morphine produces analgesia by activating mu opioid receptors encoded by the MOR–1
gene. Although morphine–6β–glucuronide (M6G), heroin and 6–acetylmorphine also are …
gene. Although morphine–6β–glucuronide (M6G), heroin and 6–acetylmorphine also are …
[HTML][HTML] Evolution of the aging brain transcriptome and synaptic regulation
Alzheimer's disease and other neurodegenerative disorders of aging are characterized by
clinical and pathological features that are relatively specific to humans. To obtain greater …
clinical and pathological features that are relatively specific to humans. To obtain greater …
Mu opioids and their receptors: evolution of a concept
GW Pasternak, YX Pan - Pharmacological reviews, 2013 - ASPET
Opiates are among the oldest medications available to manage a number of medical
problems. Although pain is the current focus, early use initially focused upon the treatment of …
problems. Although pain is the current focus, early use initially focused upon the treatment of …
Current and promising applications of Hf (IV)-based MOFs in clinical cancer therapy
X Chen, M Li, M Lin, C Lu, A Kumar, Y Pan… - Journal of Materials …, 2023 - pubs.rsc.org
Cancer is one of the greatest challenges in medical science today as it poses a serious threat
to human life. In view of this myriad of therapeutic strategies are being developed for the …
to human life. In view of this myriad of therapeutic strategies are being developed for the …
Newly synthesized homomultinuclear Co (II) and Cu (II) bissalamo‐like complexes: Structural characterizations, Hirshfeld analyses, fluorescence and antibacterial …
YQ Pan, Y Zhang, M Yu, Y Zhang… - Applied Organometallic …, 2020 - Wiley Online Library
Rare homodinuclear Co (II) complex [Co 2 (L)NO 3 ] (1) and helical centrosymmetric
homotetranuclear Cu (II) complex [Cu 4 (L) 2 (H 2 O) 2 ]·2ClO 4 (2), have been synthesized by a …
homotetranuclear Cu (II) complex [Cu 4 (L) 2 (H 2 O) 2 ]·2ClO 4 (2), have been synthesized by a …
[HTML][HTML] High-performance coherent optical modulators based on thin-film lithium niobate platform
M Xu, M He, H Zhang, J Jian, Y Pan, X Liu… - Nature …, 2020 - nature.com
The coherent transmission technology using digital signal processing and advanced modulation
formats, is bringing networks closer to the theoretical capacity limit of optical fibres, the …
formats, is bringing networks closer to the theoretical capacity limit of optical fibres, the …