The Notch signaling pathway has been implicated in both developmental processes and
tumorigenesis. Aberrant Notch signaling has been repeatedly demonstrated to facilitate the …

This work was based on our recent studies that a promising conjugate, RGD-modified
PEGylated polyamidoamine (PAMAM) dendrimer with doxorubicin (DOX) conjugated by acid-…

Zinc fingers and homeoboxes 1 (ZHX1) is a transcription repressor that has been implicated
in the tumorigenesis and progression of diverse tumors. The functional role and regulating …

Exosomes, microvesicles, and other extracellular vesicles are released by many cell types,
including cancer cells and cancer-related immune cells. Extracellular vesicles can directly or …

Background Circular RNAs (circRNAs), a newly discovered type of endogenous noncoding
RNA, have been proposed to mediate the progression of diverse types of tumors. Systematic …

Background Asparaginyl endopeptidase (AEP) has been implicated in human cancer
development. However, the molecular mechanisms underlying AEP regulation, including the role …

Forkhead transcription factor FoxO3a has been reported to have ambiguous functions and
distinct mechanisms in various solid tumors, including glioblastoma (GBM). Although a …

Tumor‐associated macrophages ( TAM ) play a critical role in promoting tumor development
and metastasis. In the present study, we found that legumain, an asparaginyl endopeptidase…

Glioblastoma multiforme (GBM) has the highest mortality rate among patients with brain
tumors, and radiotherapy forms an important part of its treatment. Thus, there is an urgent …

Elevated expression of lncRNA H19 (H19) in the setting of hypoxia has been implicated as
a promising therapeutic target for various cancers. However, little is known about the impact …