Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: opportunities, challenges and future directions for cerebral stroke management

AK Rana, D Singh - Neuropharmacology, 2018 - Elsevier
Cerebral stroke is a leading cause of early death and physical disability in adults throughout
the world. Oxidative stress and inflammation plays an important role in the pathological …

[HTML][HTML] Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury

X Chen, H Chen, M Xu, J Shen - Acta Pharmacologica Sinica, 2013 - nature.com
Ischemic stroke accounts for nearly 80% of stroke cases. Recanalization with thrombolysis is
a currently crucial therapeutic strategy for re-building blood supply, but the thrombolytic …

Peroxynitrite enhances self-renewal, proliferation and neuronal differentiation of neural stem/progenitor cells through activating HIF-1α and Wnt/β-catenin signaling …

X Chen, B Zhou, T Yan, H Wu, J Feng, H Chen… - Free Radical Biology …, 2018 - Elsevier
Hypoxic/ischemic stimulation could mediate growth and differentiation of neural
stem/progenitor cells (NSCs) into mature neurons but its underlying mechanisms are largely …

Peroxynitrite decomposition catalyst reduces delayed thrombolysis‐induced hemorrhagic transformation in ischemia‐reperfused rat brains

HS Chen, XM Chen, JH Feng, KJ Liu… - CNS neuroscience & …, 2015 - Wiley Online Library
Aim Hemorrhagic transformation (HT) is a major complication of delayed tissue plasminogen
activator (t‐PA) treatment in ischemic stroke. We aimed to explore whether peroxynitrite …

Oxidative Stress and Nitric Oxide in Cerebral Ischemic Reperfusion Injury

J Ma, Z Liu, Z Shi - Cerebral Ischemic Reperfusion Injuries (CIRI) Bench …, 2018 - Springer
Cerebral ischemic reperfusion injury is a heterogeneous phenomenon with a multi-factorial
etiology, and characterized as a cascade of neurochemical processes evolving in time and …