Ligamentum flavum fibrosis and hypertrophy: molecular pathways, cellular mechanisms, and future directions

C Sun, H Zhang, X Wang, X Liu - The FASEB Journal, 2020 - Wiley Online Library
Hypertrophy of ligamentum flavum (LF), along with disk protrusion and facet joints
degeneration, is associated with the development of lumbar spinal canal stenosis (LSCS) …

[HTML][HTML] Thickness of the ligamentum flavum: correlation with age and its asymmetry-an magnetic resonance imaging study

VS Kolte, S Khambatta, MV Ambiye - Asian spine journal, 2015 - ncbi.nlm.nih.gov
Purpose This study is an attempt to measure and compare the thickening of the LF on both
the sides with the use of magnetic resonance imaging, to investigate if there is a …

The lumbar ligamentum flavum does not have two layers and is confluent with the interspinous ligament: anatomical study with application to surgical and …

J Iwanaga, B Ishak, T Saga, A Singla… - Clinical …, 2020 - Wiley Online Library
Numerous authors over the years have reported that the lumbar ligamentum flavum has two
layers. Our routine cadaveric dissections raised the question whether this understanding is …

Lateral extent and ventral laminar attachments of the lumbar ligamentum flavum: cadaveric study

AMT Chau, NR Pelzer, J Hampton, A Smith, KA Seex… - The Spine Journal, 2014 - Elsevier
Background context Cadaveric descriptions of the deep layer of the lumbar ligamentum
flavum (LF), extending between contiguous borders of adjacent laminae and into the lateral …

[HTML][HTML] EGF contributes to hypertrophy of human ligamentum flavum via the TGF-β1/Smad3 signaling pathway

K Yang, Y Chen, X Xiang, Y Lin, C Fei… - … Journal of Medical …, 2022 - ncbi.nlm.nih.gov
Background: The most common spinal disorder in elderly is lumbar spinal canal stenosis
(LSCS). Previous studies showed that ligamentum flavum hypertrophy (LFH) with fibrosis as …

Anatomical analysis of human ligamentum flavum in the cervical spine: special consideration to the attachments, coverage, and lateral extent

MS Rahmani, H Terai, J Akhgar, A Suzuki… - Journal of Orthopaedic …, 2017 - Elsevier
Background Posterior decompression surgeries of cervical spine such as laminoplasty and
laminoforaminotomy are well established and increasing in aging population. The …

Anatomical analysis of the relation between human ligamentum flavum and posterior spinal bony prominence

J Akhgar, H Terai, MS Rahmani, K Tamai… - Journal of Orthopaedic …, 2017 - Elsevier
Background Posterior spinal bony prominences are commonly used as landmarks during
posterior spinal surgery; however, the exact relationship of these structures with ligamentum …

The midline interlaminar ligament of the spine: An anatomical study

A Millhuff, H Haddad, MS Draper, M Motzko… - Clinical …, 2023 - Wiley Online Library
Introduction During routine cadaveric dissection, Simonds et al. in 2019 found a previously
undocumented ligament, which they termed the midline interlaminar ligament (MIL), in 24 …

Anatomical analysis of the human ligamentum flavum in the thoracic spine: clinical implications for posterior thoracic spinal surgery

SA Ahmadi, A Suzuki, H Terai, K Tamai… - Journal of Orthopaedic …, 2019 - Elsevier
Background Knowledge of the ligamentum flavum anatomy is important for posterior spinal
surgery. However, only a few studies have evaluated the relationship between the thoracic …

Discovery of a new ligament of the lumbar spine: the midline interlaminar ligament

E Simonds, J Iwanaga, B Ishak, MA Reina… - The Spine Journal, 2020 - Elsevier
BACKGROUND The ligaments of the lumbar spine are integral to structural integrity and
have been well-studied. However, during the routine dissection of the lumbar spine, we …