Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Despite abundant evidence from basic/preclinical research that excessive NMDAR (N-
methyl-d-aspartate receptor) stimulation is a crucial step required for brain damage following …

Ischemic stroke is the most common type of cerebrovascular disease and is caused by an
interruption of blood flow in the brain. In this disease, two different damage areas are …

Background Skin flap transplantation is a common wound repair method in orthopedic
surgery, but skin flap necrosis remains problematic. Memantine, an excitatory amino acid …

Excessive activation of N-methyl-d-aspartate receptors (NMDARs) has been implicated in
the pathophysiology of chronic neurodegenerative diseases such as Parkinson's disease …

Stroke is an important cause of mortality and disability worldwide. Immediately after stroke
onset, the ischemic cascade initiates and deleteriously affects neural cells. Time to …

Precisely controlled synaptic glutamate concentration is essential for the normal function of
the N‐methyl D‐aspartate (NMDA) receptors. Atypical fluctuations in synaptic glutamate …

The primary mechanism for neuron death after an ischemic stroke is excitotoxic injury.
Excessive depolarization leads to NMDA-mediated calcium entry to the neuron and …

The dysfunction of N-methyl-d-Aspartate receptors (NMDARs), a subtype of glutamate
receptors, is correlated with schizophrenia, stroke, and many other neuropathological …