Background Systemic α2 agonists are believed to reduce pain and opioid requirements after
surgery, thus decreasing the incidence of opioid-related adverse effects, including …

Background Acute postoperative pain is still an issue in patients undergoing abdominal
surgery. Postoperative pain and side effects of analgesic treatment, in particular those of …

Objectives: This meta-analysis evaluated the effects of opioid-dexmedetomidine (DEX)
combinations for postoperative patient-controlled analgesia (PCA). Materials and Methods …

Background: It is still a challenge to optimize postoperative pain management. The effects of
adding dexmedetomidine (DEX) to opioid-based postoperative intravenous patient …

Background The surgical stress response plays an important role on the pathogenesis of
perioperative cardiac complications. Alpha‐2 adrenergic agonists attenuate this response …

Background: Dexmedetomidine has been shown to have an analgesic effect. However, no
consensus was reached in previous studies. Methods: Electronic databases such as …

Over 230 million people worldwide undergo surgery each year, with this number increasing
annually [1]. More than 80% of surgical patients experience acute postoperative pain …

Dexmedetomidine was initially approved for clinical use as a sedative. Its development in
pain management has been limited. Dexmedetomidine has analgesic effects and analgesic …

Background Dexmedetomidine in combination with opioids has been used for postoperative
analgesia. The purpose of this study was to investigate the impacts of dexmedetomidine …

Background The reciprocal nexus between sleep and pain is well-documented, with the
deleterious impact of operative trauma potentially playing a pivotal role in the dysregulation …