GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

A Lippa, MM Poe, JL Smith, X Jin, X Ping… - Pharmacology & …, 2022 - Elsevier
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

The evolution of corpus callosotomy for epilepsy management

A Vaddiparti, R Huang, D Blihar, M Du Plessis… - World Neurosurgery, 2021 - Elsevier
Corpus callosotomy, first used in the management of epilepsy by William P. van Wagenen in
1940, was for years a contentious procedure. Two decades later, Nobel Laureate Roger W …

Patterns of seizure spread in temporal lobe epilepsy are associated with distinct white matter tracts

E Gleichgerrcht, AS Greenblatt, TS Kellermann… - Epilepsy Research, 2021 - Elsevier
Objective It is commonly hypothesized that seizure spread patterns in patients with focal
epilepsy are associated with structural brain pathways. However, this relationship is poorly …

Using artificial intelligence to identify factors associated with autism spectrum disorder in adolescents with cerebral palsy

CM Bertoncelli, P Altamura, ER Vieira… - …, 2019 - thieme-connect.com
Autism spectrum disorder (ASD) is common in adolescents with cerebral palsy (CP) and
there is a lack of studies applying artificial intelligence to investigate this field and this …

PredictMed: A logistic regression–based model to predict health conditions in cerebral palsy

CM Bertoncelli, P Altamura, ER Vieira… - Health informatics …, 2020 - journals.sagepub.com
Logistic regression–based predictive models are widely used in the healthcare field but just
recently are used to predict comorbidities in children with cerebral palsy. This article …

Identifying factors associated with severe intellectual disabilities in teenagers with cerebral palsy using a predictive learning model

CM Bertoncelli, P Altamura, ER Vieira… - Journal of Child …, 2019 - journals.sagepub.com
Background: Intellectual disability and impaired adaptive functioning are common in
children with cerebral palsy, but there is a lack of studies assessing these issues in …

Risk factors for developing scoliosis in cerebral palsy: a cross-sectional descriptive study

CM Bertoncelli, F Solla… - Journal of child …, 2017 - journals.sagepub.com
This study aims to identify the risk factors leading to the development of severe scoliosis
among children with cerebral palsy. A cross-sectional descriptive study of 70 children (aged …

[PDF][PDF] Review of epilepsy-etiology, diagnostic evaluation and treatment

HW Shin, V Jewells, E Hadar… - Int J …, 2014 - pdfs.semanticscholar.org
Review of Epilepsy - Etiology, Diagnostic Evaluation and Treatment Page 1 Shin et al., Int J
Neurorehabilitation Eng 2014, 1:3 DOI: 10.4172/2376-0281.1000130 Open Access Review …

Validation of a clinical prediction model for the development of neuromuscular scoliosis: a multinational study

CM Bertoncelli, D Bertoncelli, L Elbaum, M Latalski… - Pediatric …, 2018 - Elsevier
Background The objective of this study was to evaluate the performance of a clinical
prediction model of neuromuscular scoliosis via external validation. Methods We analyzed a …

The positive allosteric modulator of α2/3-containing GABAA receptors, KRM-II-81, is active in pharmaco-resistant models of epilepsy and reduces hyperexcitability …

JM Witkin, G Li, LK Golani, W Xiong, JL Smith… - … of Pharmacology and …, 2020 - ASPET
The imidizodiazepine, 5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo [f] imidazo [1, 5-a][1, 4]
diazepin-3-yl) oxazole (KRM-II-81), is selective for α2/3-containing GABA A receptors. KRM …