Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments

E Gambeta, JG Chichorro, GW Zamponi - Molecular pain, 2020 - journals.sagepub.com
The trigeminal nerve (V) is the fifth and largest of all cranial nerves, and it is responsible for
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …

A comprehensive review of trigeminal neuralgia

MR Jones, I Urits, KP Ehrhardt, JN Cefalu… - Current pain and …, 2019 - Springer
Abstract Purpose of Review Trigeminal neuralgia (TN) is characterized by recurrent attacks
of lancinating facial pain in the dermatomal distribution of the trigeminal nerve. TN is rare …

Trigeminal neuralgia: current approaches and emerging interventions

R Xu, ME Xie, CM Jackson - Journal of pain research, 2021 - Taylor & Francis
Trigeminal neuralgia (TN) has been described in the literature as one of the most debilitating
presentations of orofacial pain. This review summarizes over 150 years of collective clinical …

[HTML][HTML] Chronic facial pain: Trigeminal neuralgia, persistent idiopathic facial pain, and myofascial pain syndrome—an evidence-based narrative review and …

R Gerwin - International journal of environmental research and …, 2020 - mdpi.com
Trigeminal neuralgia (TN), the most common form of severe facial pain, may be confused
with an ill-defined persistent idiopathic facial pain (PIFP). Facial pain is reviewed and a …

[HTML][HTML] Pathological mechanisms and therapeutic targets for trigeminal neuropathic pain

P Bista, WL Imlach - Medicines, 2019 - mdpi.com
Trigeminal neuropathic pain is a chronic pain condition caused by damage or inflammation
of the trigeminal nerve or its branches, with both peripheral and central nervous system …

The state-of-the-art pharmacotherapeutic options for the treatment of chronic non-cancer pain

RS D'Souza, B Langford, RE Wilson… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Pharmacotherapeutic options continue to expand for the treatment of chronic
non-cancer pain. There has been an increasing emphasis on multimodal analgesia. This …

[HTML][HTML] Neuropathic pain and sleep: a review

L Ferini-Strambi - Pain and therapy, 2017 - Springer
Neuropathic pain is associated with sleep disturbances, and in turn poor sleep quality leads
to increased pain sensitivity, so it is essential to assess sleep alongside neuropathic pain …

Is percutaneous balloon compression better than microvascular decompression to treat trigeminal neuralgia? A systematic review and meta-analysis

RFV Nascimento, LZ Pipek, PHP de Aguiar - Journal of Clinical …, 2023 - Elsevier
Background Trigeminal neuralgia (TN) is a neuropathic pain that affects one or more
branches of the trigeminal nerve. Surgical options after pharmacological failure are …

Glutamatergic systems in neuropathic pain and emerging non-opioid therapies

R Temmermand, JE Barrett, ACK Fontana - Pharmacological research, 2022 - Elsevier
Neuropathic pain, a disease of the somatosensory nervous system, afflicts many individuals
and adequate management with current pharmacotherapies remains elusive. The …

[PDF][PDF] Exome sequencing implicates impaired GABA signaling and neuronal ion transport in trigeminal neuralgia

W Dong, SC Jin, A Allocco, X Zeng, AH Sheth… - IScience, 2020 - cell.com
Trigeminal neuralgia (TN) is a common, debilitating neuropathic face pain syndrome often
resistant to therapy. The familial clustering of TN cases suggests that genetic factors play a …