Antiepileptic drugs (AEDs) have many benefits but also many side effects, including
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …

Effective treatment of epilepsy depends on medication compliance across a lifetime, and
studies indicate that drug tolerability is a significant limiting factor in medication …

Lennox-Gastaut syndrome is one of the most severe epileptic encephalopathies of
childhood onset. The cause of this syndrome can be symptomatic (ie, secondary to an …

Cerebral palsy (CP) is a common pediatric disorder occurring in about 2 to 2.5 per 1000 live
births. It is a chronic motor disorder resulting from a non-progressive (static) insult to the …

Objective: To evaluate efficacy and safety of clobazam, a 1, 5-benzodiazepine, as adjunctive
therapy for Lennox-Gastaut syndrome (LGS). Methods: Patients aged 2–60 years were …

The literature was evaluated for cognitive and more general behavioural effects. We
distinguished the older antiepileptic drugs (AEDs), from the newer and newest AEDs. The …

Purpose: This randomized, double‐blind, dose‐ranging study evaluated safety and efficacy
of clobazam (CLB) as adjunctive therapy for drop seizures in patients with Lennox‐Gastaut …

Children with epilepsy have high rates of sleep problems. Melatonin has been advocated in
treatment of sleep disorders, and its beneficial effect has been confirmed in insomnia. The …

Catastrophic childhood epilepsies such as infantile spasms (IS), progressive myoclonic
epilepsy, and Lennox-Gastaut syndrome (LGS) are rare but debilitating and frequently …

Patient tolerability is a significant limiting factor in the treatment of epilepsy and adverse
effect profiles often determine drug retention rates. A full appreciation of the behavioral …