OBJECTIVE: The aim of the study is to determine: 1) the frequency of patients admitted for
phenytoin toxicity and their economic burden; 2) the clinical symptoms and signs of …

Phenytoin intoxication can occur either with repeated supra therapeutic dosing or an acute
overdose. Dose-dependent CNS depression occurs. Most presentations are benign and …

Phenytoin is a widely prescribed antiepileptic drug used for the management of most seizure
disorders. It has complicated non linear pharmacokinetic, it is highly protein bound, has a …

(1) National Centre of Pharmacovigilance, Tunisia Introduction: Phenytoin (PHT) is a
commonly used anticonvulsant medication. PHT intoxication may be responsible of central …

DISCUSSION: Phenytoin has narrow therapeutic index of 10-20 mcg/mL which carries a risk
of potential toxicity with daily use. With high concentrations elimination shifts from first order …

Phenytoin is a commonly prescribed antiepileptic drug. Due to its saturation (zero-order)
pharmacokinetics, phenytoin carries a special risk of dose-related toxicity that is an …

We present a series of cases of phenytoin toxicity where the diagnosis was initially missed.
These patients all suffered unnecessary morbidity or investigations. The side‐effects and …

Phenytoin is the oldest sedative antiepileptic drug and one of the most widely prescribed
antiepileptic drug effective against all types of partial and tonic-clonic seizures except in …

Phenytoin toxicity may result from intentional overdose, dosage adjustments, drug
interactions, or alterations in physiology. Intoxication manifests predominantly as nausea …

Phenytoin toxicity occurs when serum levels exceed the therapeutic level, leading to
symptoms such as nystagmus, slurred speech, and decreased coordination. This toxicity is …