Brain dopaminergic receptor activation, either by levodopa or by direct dopamine receptor
agonists, remains the bulwark of treatment of Parkinson's disease. 1 Levodopa and direct …

Objective: The aim of this research was to trace the rich and eventful history of apomorphine,
bringing to light some of the forgotten names associated with it. Background: Apomorphine …

We performed a microdialysis investigation of extracellular amino acid (glutamate and
GABA) concentrations during sterotaxic neurosurgery (the implantation of permanent …

Morphine is reported both to antagonize apomorphineinduced stereotyped behaviour (ASB)
in the rat (Janssen, Niemegeers & Jageneau, 1960; Kuschinsky & Hornykiewicz, 1972; Puri …

This study was carried out to evaluate the postulated dopaminergic autoreceptor regulatory
effect in man of low-dose apomorphine. Behavior and serum homovanillic acid …

The pharmacological basis of the short‐duration response to dopaminergic stimulation in
parkinsonism is not completely understood. Whereas it is generally assumed that the …

Abstract l-3, 4-Dihydroxyphenylalanine (l-DOPA) has been believed to be an inert amino
acid precursor of dopamine, and is the most effective therapeutic agent in Parkinson's …

We monitored the motor response and plasma and ventricular CSF (CSFV) concentrations
of L-dopa during IV infusions of L-dopa in two patients with advanced Parkinson's disease …

We performed a microdialysis investigation of extracellular amino acid (glutamate and
GABA) concentrations during sterotaxic neurosurgery (the implantation of permanent …

Apmorphine, a potent dopamine agonist, has been used in acute and chronic studies of
parkinsonism and other neurological disorders. To define its peripheral pharmacokinetics …